Lushnikov K V, Gapeev A B, Chemeris N K
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia.
Radiats Biol Radioecol. 2002 Sep-Oct;42(5):533-45.
Low-intensity of electromagnetic radiation of extremely high frequencies (EHF EMR) is effectively used in medical practice for diagnostics, prevention and treatment of a broad spectrum of diseases of different etiology. However, in spite of existence of many hypotheses about mechanisms of EHF EMR effects on the molecular and cellular levels of organization of living systems, there is not conception that could explain all diversity of the EHF-therapy effects from unified approach. In our opinion, the problem of determination of mechanisms of EHF EMR effects on living organism is divided into two basic tasks: first, determining subcellular structures which can receive radiation, and, second, studying physiological reactions of the organism which are caused by radiation. It is obviously, that investigation of functions of single cells and subcellular elements can not entirely explain therapeutic effects and mechanisms of EHF EMR influence on multicellular organism on the whole. Plenty of functional relationships between organs and systems of organs should be taken into account. In the present review, a realization of the EHF-therapy effects due to the influence on immune system functions and start of system mechanisms of maintenance of the homeostasis on the organism level is hypothesized. Potential targets for EHF EMR acception on the level of different systems of the organism are analysed. The material is formed so that functional relations between immune system and other regulatory systems (nervous and endocrine systems) are traced.
极高频电磁辐射（EHF EMR）的低强度在医学实践中被有效地用于诊断、预防和治疗各种不同病因的疾病。然而，尽管存在许多关于EHF EMR在生命系统组织的分子和细胞水平上作用机制的假说，但尚无一种概念能够从统一的方法解释EHF治疗效果的所有多样性。我们认为，确定EHF EMR对生物体作用机制的问题可分为两个基本任务：第一，确定能够接收辐射的亚细胞结构；第二，研究由辐射引起的生物体的生理反应。显然，对单细胞和亚细胞成分功能的研究并不能完全解释EHF EMR对多细胞生物体整体的治疗效果和影响机制。应该考虑器官与器官系统之间大量的功能关系。在本综述中，假设EHF治疗效果是由于对免疫系统功能的影响以及在生物体水平上启动维持内稳态的系统机制而实现的。分析了生物体不同系统水平上EHF EMR接受的潜在靶点。材料的形成方式是追踪免疫系统与其他调节系统（神经和内分泌系统）之间的功能关系。
