Gapeyev Andrew B, Kulagina Tatiana P, Aripovsky Alexander V, Chemeris Nikolay K
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Bioelectromagnetics. 2011 Jul;32(5):388-95. doi: 10.1002/bem.20645. Epub 2011 Feb 1.
The effects of low-intensity extremely high-frequency electromagnetic radiation (EHF EMR; 42.2 GHz, 0.1 mW/cm(2) , exposure duration 20 min) on the fatty acid (FA) composition of thymic cells and blood plasma in normal mice and in mice with peritoneal inflammation were studied. It was found that the exposure of normal mice to EHF EMR increased the content of polyunsaturated FAs (PUFAs) (eicosapentaenoic and docosapentaenoic) in thymic cells. Using a model of zymosan-induced peritoneal inflammation, it was shown that the exposure of mice to EHF EMR significantly increased the content of PUFAs (dihomo-γ-linolenic, arachidonic, eicosapentaenoic, docosapentaenoic, and docosahexaenoic) and reduced the content of monounsaturated FAs (MUFAs) (palmitoleic and oleic) in thymic cells. Changes in the FA composition in the blood plasma were less pronounced and manifested themselves as an increase in the level of saturated FAs during the inflammation. The data obtained support the notion that MUFAs are replaced by PUFAs that can enter into the thymic cells from the external media. Taking into account the fact that the metabolites of PUFAs are lipid messengers actively involved in inflammatory and immune reactions, we assume that the increase in the content of n-3 and n-6 PUFAs in phospholipids of cellular membranes facilitates the realization of anti-inflammatory effects of EHF EMR.
研究了低强度极高频电磁辐射（EHF EMR；42.2 GHz，0.1 mW/cm²，暴露持续时间20 分钟）对正常小鼠和患有腹膜炎症小鼠胸腺细胞及血浆脂肪酸（FA）组成的影响。发现正常小鼠暴露于EHF EMR会增加胸腺细胞中多不饱和脂肪酸（PUFA）（二十碳五烯酸和二十二碳五烯酸）的含量。使用酵母聚糖诱导的腹膜炎症模型表明，小鼠暴露于EHF EMR会显著增加胸腺细胞中PUFA（二高-γ-亚麻酸、花生四烯酸、二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸）的含量，并降低单不饱和脂肪酸（MUFA）（棕榈油酸和油酸）的含量。血浆中FA组成的变化不太明显，表现为炎症期间饱和脂肪酸水平的升高。获得的数据支持以下观点，即MUFA被可从外部介质进入胸腺细胞的PUFA所取代。考虑到PUFA的代谢产物是积极参与炎症和免疫反应的脂质信使，我们假设细胞膜磷脂中n-3和n-6 PUFA含量的增加有助于实现EHF EMR的抗炎作用。
