Headley P M, Lodge D
Brain Res. 1976 Jan 23;101(3):445-59. doi: 10.1016/0006-8993(76)90470-4.
Field and unitary action potentials have been recorded in the inferior olivary complex of pentobarbital anaesthetized rats. Spontaneous and antidromically evoked unitary potentials, and antidromically evoked field potentials all showed the same biphasic profile. Repetitive antidromic stimulation resulted in attenuation of the field potential with stimulation frequencies as low as 10 Hz. The latency of juxtafastigially evoked spikes was variable, and decreased with increasing stimulus strengths. Electrophoretically applied glycine, gamma-aminobutyric acid, noradrenaline, dopamine and 5-hydroxytyptamine all reduced the amplitude of the antidromic potential, but sometimes caused a transient increase preceding this decrease. Orthodromically (femoral nerve) evoked potentials were different in form and could assume one of two distinct profiles. The effects of electrophoretically applied DL-homocysteate (DLH) and the putative transmitters listed above on the form of such field potentials are described. DLH, ACh and 5-HT were tested on single olivary neurones, which had spontaneous firing rates of less than 2 Hz. These compounds had only slight effects on firing rates although marked changes were seen in action potential configuration. Spontaneous synchronous discharges of groups of olivary neurones are described. This and other findings confirm that olivary units have a tendency to both rhythmical and synchronous firing.
在戊巴比妥麻醉的大鼠下橄榄核复合体中记录到了场电位和单位动作电位。自发和逆向诱发的单位电位以及逆向诱发的场电位均呈现相同的双相波形。重复逆向刺激在低至10 Hz的刺激频率下就会导致场电位衰减。近顶核诱发的锋电位潜伏期可变，并随刺激强度增加而缩短。电泳施加甘氨酸、γ-氨基丁酸、去甲肾上腺素、多巴胺和5-羟色胺均降低了逆向电位的幅度，但有时在降低之前会引起短暂增加。顺向（股神经）诱发的电位在形式上有所不同，可呈现两种不同波形之一。描述了电泳施加DL-高半胱氨酸（DLH）和上述假定递质对这种场电位形式的影响。在自发放电频率低于2 Hz的单个橄榄核神经元上测试了DLH、乙酰胆碱和5-羟色胺。这些化合物对放电频率只有轻微影响，尽管动作电位形态有明显变化。描述了橄榄核神经元群的自发同步放电。这一发现和其他发现证实橄榄核单位有节律性和同步放电的倾向。
