下橄榄核中眨眼条件反射和神经元活动的发育变化。
Developmental changes in eye-blink conditioning and neuronal activity in the inferior olive.
作者信息
Nicholson D A, Freeman J H
机构信息
Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA.
出版信息
J Neurosci. 2000 Nov 1;20(21):8218-26. doi: 10.1523/JNEUROSCI.20-21-08218.2000.
Abstract
Neuronal activity was recorded in the dorsal accessory inferior olive in infant rats during classical conditioning of the eye-blink response. The percentage and amplitude of eye-blink conditioned responses (CRs) increased as a function of age. The magnitude of the neuronal response to the unconditioned stimulus (US) decreased with age. There were also age-specific modifications of US-elicited inferior olive neuronal activity during paired trials in which a conditioned eye-blink response was performed. The results indicate that the development of the conditioned eye-blink response may depend on dynamic interactions between multiple developmental processes within the eye-blink circuitry. Differences in the functional maturity of olivo-cerebellar pathways may limit the induction of plasticity in the cerebellum and thereby limit the development of eye-blink conditioned responses.
摘要
在幼鼠眨眼反应的经典条件反射过程中，记录了其背侧副下橄榄核中的神经元活动。眨眼条件反应（CRs）的百分比和幅度随年龄增长而增加。对非条件刺激（US）的神经元反应强度随年龄下降。在进行眨眼条件反应的配对试验中，US诱发的下橄榄核神经元活动也存在年龄特异性变化。结果表明，眨眼条件反应的发展可能取决于眨眼回路中多个发育过程之间的动态相互作用。橄榄小脑通路功能成熟度的差异可能会限制小脑可塑性的诱导，从而限制眨眼条件反应的发展。
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