Ruaro B, Sulli A, Alessandri E, Fraternali-Orcioni G, Cutolo M
Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy.
Department of Pathology, Anatomic Pathology Division, San Martino University Hospital, Genova, Italy.
Lupus. 2014 Aug;23(9):939-44. doi: 10.1177/0961203314530794. Epub 2014 Apr 16.
Kikuchi-Fujimoto's disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign and self-limiting disease of unknown aetiology. KFD tends to affect a young population under 30 years of age and predominantly females. KFD is a rare pathology and its association with systemic lupus erythematosus (SLE) is not frequent. Herein, we present the case of a male Italian patient with SLE in association with KFD with 5 years of follow-up, where a differential diagnosis from infection or lymphoproliferative disease was problematic.
菊池-藤本病（KFD），即组织细胞坏死性淋巴结炎，是一种病因不明的良性自限性疾病。KFD 倾向于影响 30 岁以下的年轻人群，且以女性为主。KFD 是一种罕见的病理情况，其与系统性红斑狼疮（SLE）的关联并不常见。在此，我们报告一例患有 SLE 并合并 KFD 的意大利男性患者，对其进行了 5 年的随访，该病例在与感染或淋巴增殖性疾病进行鉴别诊断时存在困难。
