Sasai Hisanori, Watanabe Yusuke, Miyahara Hiroshi
Department of Otolaryngology-Head and Neck Surgery, Mita Hospital International University of Health & Welfare, Tokyo.
Nihon Jibiinkoka Gakkai Kaiho. 2009 Aug;112(8):623-7. doi: 10.3950/jibiinkoka.112.623.
We studied the long-term histological response of the human larynx to Gore-Tex implant and evaluated whether its biocompatibility.
Retrospective histological study.
We conducted medialization laryngoplasty with expanded polytetrafluoroethylene (ePTEE or Gore-Tex) in a patient with vocal-fold paralysis. A strip of Gore-Tex was folded several times and inserted into the pocket preserving the inner perichondrium through a thyroid cartilage window. The patient died 12 months later and we histologically analyzed the larynx.
No evidence was seen of foreign body granuloma, migration, extrusion, or infection. A modest inflammatory response with a fibrous capsule was present around implants. We confirmed the infiltration of abundant collagen and numerous fibroblasts into the microporous implant structure.
Histological examination results suggest that Gore-Tex implants are safe and biocompatible with the human larynx. A slight inflammatory response and infiltration of fibrous tissue into the implant itself demonstrated that Gore-Tex implants are immunologically well tolerated.
我们研究了人类喉部对戈尔特斯植入物的长期组织学反应，并评估其生物相容性。
回顾性组织学研究。
我们对一名声带麻痹患者进行了膨体聚四氟乙烯（ePTEE或戈尔特斯）喉内移术。将一条戈尔特斯材料折叠几次，通过甲状软骨窗口插入保留内层软骨膜的囊袋中。患者12个月后死亡，我们对喉部进行了组织学分析。
未发现异物肉芽肿、迁移、挤出或感染的证据。植入物周围存在伴有纤维囊的适度炎症反应。我们证实大量胶原蛋白和众多成纤维细胞浸润到微孔植入物结构中。
组织学检查结果表明，戈尔特斯植入物是安全的，并且与人类喉部具有生物相容性。轻微的炎症反应以及纤维组织向植入物本身的浸润表明，戈尔特斯植入物在免疫方面具有良好的耐受性。
