Morrell C N, Volk M V, Mankowski J L
Vet Pathol. 2002 Nov;39(6):756-8. doi: 10.1354/vp.39-6-756.
A cholecystectomy was performed on a 10-year-old spayed female mixed-breed dog with chronic weight loss, persistently increased liver enzyme activities, and cholecystomegaly identified by ultrasonographic examination. A subsequent diagnosis of a biliary carcinoid was made based on a neuroendocrine-type histologic pattern, cytoplasmic argyrophilia by Grimelius staining, immunopositivity for chromogranin A, and the ultrastructural finding of cytoplasmic secretory granules in neoplastic cells. Extrahepatic biliary carcinoid tumors are rare tumors of humans and have not been documented in domestic animals.
对一只10岁已绝育的雌性混种犬实施了胆囊切除术，该犬存在慢性体重减轻、肝酶活性持续升高，且超声检查发现胆囊增大。随后，根据神经内分泌型组织学模式、Grimelius染色显示的细胞质嗜银性、嗜铬粒蛋白A免疫阳性以及肿瘤细胞中细胞质分泌颗粒的超微结构发现，诊断为胆管类癌。肝外胆管类癌肿瘤在人类中是罕见肿瘤，在家畜中尚无记录。
