Osendarp Saskia J M, Santosham Mathuram, Black Robert E, Wahed M A, van Raaij Joop M A, Fuchs George J
International Center for Diarrhoeal Disease Research, Bangladesh (ICDDR,B): Centre for Health and Population Research, Dhaka, Bangladesh.
Am J Clin Nutr. 2002 Dec;76(6):1401-8. doi: 10.1093/ajcn/76.6.1401.
Evidence for an effect of zinc supplementation on growth and morbidity in very young infants in developing countries is scarce and inconsistent.
We assessed the effect of zinc supplementation on growth and morbidity in poor Bangladeshi infants aged 4-24 wk.
Infants from Dhaka slums were enrolled at 4 wk of age and randomly assigned to receive 5 mg elemental Zn/d (n = 152) or placebo (n = 149) until 24 wk of age. They were followed weekly for information on compliance and morbidity; anthropometric measurements were performed monthly. Serum zinc was assessed at baseline and at 24 wk of age.
At 24 wk of age, serum zinc concentrations were higher in the zinc than in the placebo group (13.3 +/- 3.8 and 10.7 +/- 2.9 micro mol/L, respectively; P < 0.001). Significantly greater weight gains were observed in the zinc than in the placebo group for 43 infants who were zinc deficient (< 9.18 micro mol/L) at baseline (3.15 +/- 0.77 and 2.66 +/- 0.80 kg, respectively; P < 0.04). In the other infants, no significant differences were observed in mean weight and length gains during the study period. Zinc-deficient infants showed a reduced risk of incidence of acute lower respiratory infection after zinc supplementation (relative risk: 0.30; 95% CI: 0.10, 0.92); among the non-zinc-deficient infants there were no significant differences between treatment groups.
Zinc-deficient Bangladeshi infants showed improvements in growth rate and a reduced incidence of acute lower respiratory infection after zinc supplementation. In infants with serum zinc concentrations > 9.18 micro mol/L, supplementation improved only biochemical zinc status.
关于在发展中国家极幼龄婴儿中补充锌对生长和发病率影响的证据稀缺且不一致。
我们评估了补充锌对孟加拉国4至24周龄贫困婴儿生长和发病率的影响。
来自达卡贫民窟的婴儿在4周龄时入组，并随机分配接受5毫克元素锌/天（n = 152）或安慰剂（n = 149），直至24周龄。每周对他们进行随访以获取依从性和发病率信息；每月进行人体测量。在基线和24周龄时评估血清锌。
在24周龄时，锌组的血清锌浓度高于安慰剂组（分别为13.3±3.8和10.7±2.9微摩尔/升；P<0.001）。对于基线时锌缺乏（<9.18微摩尔/升）的43名婴儿，锌组的体重增加显著大于安慰剂组（分别为3.15±0.77和2.66±0.80千克；P<0.04）。在其他婴儿中，研究期间平均体重和身长增加无显著差异。锌缺乏婴儿补充锌后急性下呼吸道感染的发病风险降低（相对风险：0.30；95%置信区间：0.10，0.92）；在非锌缺乏婴儿中，治疗组之间无显著差异。
孟加拉国锌缺乏婴儿补充锌后生长速率有所改善，急性下呼吸道感染发病率降低。在血清锌浓度>9.18微摩尔/升的婴儿中，补充锌仅改善了生化锌状态。
