Csernansky John G, Wang Lei, Jones Donald, Rastogi-Cruz Devna, Posener Joel A, Heydebrand Gitry, Miller J Philip, Miller Michael I
Department of Psychiatry (Box 8134), Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
Am J Psychiatry. 2002 Dec;159(12):2000-6. doi: 10.1176/appi.ajp.159.12.2000.
Abnormalities of hippocampal structure have been reported in schizophrenia subjects. However, such abnormalities have been difficult to discriminate from normal neuroanatomical variation. High dimensional brain mapping, which utilizes probabilistic deformations of a neuroanatomical template, was used to characterize disease-related patterns of changes in hippocampal volume, shape, and asymmetry.
T(1)-weighted magnetic resonance scans were collected in 52 schizophrenia and 65 comparison subjects who were similar in age, gender, and parental socioeconomic status. The schizophrenia subjects were clinically stable at the time of assessment.
Significant abnormalities of hippocampal shape and asymmetry (but not volume after total cerebral volume was included as a covariate) were found in the schizophrenia subjects. The pattern of shape abnormality suggested a neuroanatomical deformity of the head of the hippocampus, which contains neurons that project to the frontal cortex. The pattern of hippocampal asymmetry observed in the schizophrenia subjects suggested an exaggeration of the asymmetry pattern observed in the comparison subjects. No correlations were found between the magnitude of hippocampal shape and asymmetry abnormality and the severity of residual symptoms or duration of illness.
Schizophrenia is associated with structural deformities of the hippocampus, which suggest a disturbance of the connections between the hippocampus and the frontal cortex. However, the magnitude of these deformities are not related to severity or duration of illness.
已有报道称精神分裂症患者存在海马结构异常。然而，这种异常难以与正常神经解剖变异区分开来。利用神经解剖模板的概率变形的高维脑图谱被用于描绘与疾病相关的海马体积、形状和不对称性变化模式。
对52名精神分裂症患者和65名年龄、性别及父母社会经济地位相似的对照受试者进行了T(1)加权磁共振扫描。精神分裂症患者在评估时临床症状稳定。
在精神分裂症患者中发现了海马形状和不对称性（但在将全脑体积作为协变量纳入后体积无异常）的显著异常。形状异常模式表明海马头部存在神经解剖畸形，海马头部包含投射到额叶皮质的神经元。在精神分裂症患者中观察到的海马不对称模式表明，其不对称模式比对照受试者更为明显。未发现海马形状和不对称性异常程度与残留症状严重程度或病程之间存在相关性。
精神分裂症与海马结构畸形有关，这表明海马与额叶皮质之间的连接受到干扰。然而，这些畸形的程度与疾病的严重程度或病程无关。
