Tepest Ralf, Wang Lei, Miller Michael I, Falkai Peter, Csernansky John G
Department of Psychiatry (RT), University of Bonn Medical Center, Bonn, Germany.
Biol Psychiatry. 2003 Dec 1;54(11):1234-40. doi: 10.1016/s0006-3223(03)00702-9.
Neuroanatomical abnormalities have been reported in schizophrenia subjects and their relatives and may be related to genetic vulnerability. The objective of this study was to further elucidate hippocampal deformities as a marker of genetic vulnerability for schizophrenia.
Magnetic resonance scans were collected in 13 pairs of schizophrenics and their unaffected siblings from families with multiple affected members, in 12 schizophrenics from families without another affected member, and in 10 healthy controls. Hippocampal volume and shape were compared using large-deformation high-dimensional brain mapping.
Decreases in hippocampal volume, covaried for total cerebral volume, were observed in the schizophrenia subjects from families with multiple affected members, as well as in their unaffected siblings. Shape analysis demonstrated that both groups of schizophrenia subjects, as well as the unaffected siblings, could be distinguished from the controls; however, no significant difference in hippocampal shape was found between the schizophrenia subjects and their unaffected siblings. Visualization of the pattern of hippocampal shape deformity in both groups of schizophrenia subjects and in the unaffected siblings showed inward deformities of the head of the hippocampus.
Deformations of hippocampal anatomy may be related to the genetic vulnerability of acquiring schizophrenia.
已有报道称精神分裂症患者及其亲属存在神经解剖学异常，且这些异常可能与遗传易感性有关。本研究的目的是进一步阐明海马体畸形作为精神分裂症遗传易感性的标志物。
收集了来自有多例患者的家庭的13对精神分裂症患者及其未患病的兄弟姐妹、来自无其他患者的家庭的12例精神分裂症患者以及10名健康对照者的磁共振扫描图像。使用大变形高维脑图谱比较海马体体积和形状。
在有多例患者的家庭的精神分裂症患者及其未患病的兄弟姐妹中，观察到校正全脑体积后的海马体体积减小。形状分析表明，两组精神分裂症患者及其未患病的兄弟姐妹均能与对照组区分开来；然而，精神分裂症患者与其未患病的兄弟姐妹之间在海马体形状上未发现显著差异。两组精神分裂症患者及其未患病的兄弟姐妹的海马体形状畸形模式可视化显示海马体头部向内畸形。
海马体解剖结构的畸形可能与患精神分裂症的遗传易感性有关。
