Sharshar T, Durand M-C, Lefaucheur J-P, Lofaso F, Raphaël J-C, Gherardi R K, Créange A
Réseau de Neuroimmunologie du Nerf Périphérique, Université de Paris, France.
Neurology. 2002 Nov 26;59(10):1649-51. doi: 10.1212/01.wnl.0000033799.58866.7a.
To investigate the role of MMP-9 in Guillain-Barré syndrome, the authors correlated electrophysiologic abnormalities and MMP-9 plasma levels in a series of 21 patients. MMP-9 plasma levels were higher in the demyelinating group than in the nondemyelinating group, and in patients with high CSF protein level. Increase of MMP-9 circulating levels correlated with the increase of F waves latencies, reduction of CMAP amplitude, and decrease of nerve conduction velocities. Circulating MMP-9 may contribute to the peripheral nerve dysfunction of demyelinating Guillain-Barré syndrome.
为研究基质金属蛋白酶-9（MMP-9）在吉兰-巴雷综合征中的作用，作者对21例患者的电生理异常与血浆MMP-9水平进行了相关性分析。脱髓鞘组的血浆MMP-9水平高于非脱髓鞘组，且脑脊液蛋白水平高的患者血浆MMP-9水平也较高。MMP-9循环水平的升高与F波潜伏期延长、复合肌肉动作电位（CMAP）波幅降低及神经传导速度减慢相关。循环中的MMP-9可能参与了脱髓鞘型吉兰-巴雷综合征的周围神经功能障碍。
