Aatif Taoufiq, Labioui Narjiss, Laasli Hajjar, Zajjari Yassir, Kabbaj Driss El
Department of Nephrology Dialysis and Renal Transplantation, Mohammed V Military Hospital, UM5, Rabat, Morocco.
Ann Indian Acad Neurol. 2025 Jul 1;28(4):590-593. doi: 10.4103/aian.aian_74_25. Epub 2025 Jun 28.
Chronic kidney disease is a global public health problem. Emphasis has been placed on uremic peripheral neuropathy (PN) in nondiabetic chronic hemodialysis (HD) patients. This complication could affect the quality of life. We aimed to determine the prevalence and risk factors of PN. This was a cross-sectional study. Evaluation of PN was made by clinical examination and electroneuromyogram. The prevalence of PN was 30.3%. The most common symptoms were paresthesia and burning. Neuropathic pain was symmetrical in the majority of cases and localized to the lower limb (60%). All patients had axonal type PN. In univariate analysis, the risk factors for PN were advanced age ( P = 0.012), hypertension ( P = 0.007), ischemic heart disease ( P = 0.036), high C-reactive protein (microinflammation) ( P = 0.002), low urea reduction ratio ( P = 0.013), and high ß2 microglobulin ( P = 0.002). Since PN is common in nondiabetic chronic HD patients, it becomes necessary to diagnose it and correct its risk factors.
慢性肾脏病是一个全球性的公共卫生问题。非糖尿病慢性血液透析（HD）患者的尿毒症周围神经病变（PN）已受到关注。这种并发症会影响生活质量。我们旨在确定PN的患病率及危险因素。这是一项横断面研究。通过临床检查和神经电生理检查对PN进行评估。PN的患病率为30.3%。最常见的症状是感觉异常和烧灼感。在大多数病例中，神经病理性疼痛是对称的，且多局限于下肢（60%）。所有患者均为轴索性PN。单因素分析显示，PN的危险因素包括高龄（P = 0.012）、高血压（P = 0.007）、缺血性心脏病（P = 0.036）、高C反应蛋白（微炎症）（P = 0.002）、低尿素清除率（P = 0.013）和高β2微球蛋白（P = 0.002）。由于PN在非糖尿病慢性HD患者中很常见，因此有必要对其进行诊断并纠正其危险因素。
