Krüger C, Teller W M
Z Kinderheilkd. 1975;119(4):253-9. doi: 10.1007/BF00443509.
The contents of acid glycosaminoglycans (aGAG) was determined in the inner and medial layers of aortae from 13 newborns, 9 small children (1-5 years of age), and 10 older adults (7th decade of life). The total aGAG contents was expressed in mug hexuronic acid/100 mg dry weight. Newborns and older adults showed similiar contents of aGAG in their aortae (275.5 plus or minus 27.9 and 313.4 plus or minus 46.7, respectively). Small children had significantly less aGAG in their aortae (202.1 plus or minus 21.5). The aGAG material from aortae was fractionated by a microcolumn chromatographic procedure on cetylpyridinium chloride cellulose. No significant differences of the aGAG fractions were found in aortae of newborns and children. In both groups of children the percentage of hyaluronic acid was significantly increased and dermatan sulfate was significantly decreased when compared with aortae from older adults. The increased contents of acid glycosaminoglycans (aGAG) in aortae of human newborns is possibly caused by the concentrated hormonal environment (especially estrogens) to which the fetus is exposed in utero.
测定了13名新生儿、9名小儿（1 - 5岁）和10名老年人（70岁左右）主动脉内层和中层的酸性糖胺聚糖（aGAG）含量。总aGAG含量以微克己糖醛酸/100毫克干重表示。新生儿和老年人主动脉中的aGAG含量相似（分别为275.5±27.9和313.4±46.7）。小儿主动脉中的aGAG含量明显较少（202.1±21.5）。通过在氯化十六烷基吡啶纤维素上的微柱色谱法对主动脉中的aGAG物质进行分级分离。在新生儿和小儿的主动脉中未发现aGAG级分有显著差异。与老年人的主动脉相比，两组儿童中透明质酸的百分比显著增加，硫酸皮肤素显著减少。人类新生儿主动脉中酸性糖胺聚糖（aGAG）含量增加可能是由于胎儿在子宫内所接触的浓缩激素环境（尤其是雌激素）所致。
