Murata K, Akashio K, Ochiai Y
Hepatogastroenterology. 1984 Dec;31(6):261-5.
Acidic glycosaminoglycan (AGAG) components in normal human liver and at different stages of liver cirrhosis were studied at the constitutional disaccharide level by enzymatic assay methods. The AGAG content in human cirrhotic liver was 5-6 times that in the normal state. The most predominant AGAG components in normal human liver tissue were heparan sulfates (HS) which accounting for 63% of the total AGAG, followed by a moderate amount of dermatan sulfate (DS) and small amounts of chondroitin sulfate isomers and hyaluronic acid (HA). In addition, the oversulfated DS detected in human liver. The increase in both HS and DS content reflects an increase in total AGAG with advancing liver cirrhosis. The ratio of non-sulfated AGAG, HA plus chondroitin, to DS plus its oversulfated isomer was 0.24 in the normal state but it increased to 0.80 at the early stage of liver cirrhosis. However, the ratio decreased to 0.36 and 0.21 at the typical and advanced stages of liver cirrhosis, respectively, with progress in the fibrotic process.
采用酶法在组成二糖水平上研究了正常人肝脏及肝硬化不同阶段的酸性糖胺聚糖（AGAG）成分。人肝硬化肝脏中的AGAG含量是正常状态下的5至6倍。正常人肝组织中最主要的AGAG成分是硫酸乙酰肝素（HS），占总AGAG的63%，其次是适量的硫酸皮肤素（DS）以及少量的硫酸软骨素异构体和透明质酸（HA）。此外，在人肝脏中检测到了过度硫酸化的DS。随着肝硬化进展，HS和DS含量的增加反映了总AGAG的增加。在正常状态下，非硫酸化AGAG（HA加软骨素）与DS及其过度硫酸化异构体的比例为0.24，但在肝硬化早期增加到0.80。然而，随着纤维化进程的发展，在肝硬化典型期和晚期该比例分别降至0.36和0.21。
