Stephany W, Gierlichs H W, Planz G, Rahn K H, Heintz R
Dtsch Med Wochenschr. 1976 Jan 2;101(1):9-13. doi: 10.1055/s-0028-1104024.
All drug side-effects - definite, probable and suspected - were noted during one year in 1592 patients. The severity of the side-effects was classified into mild (15%), moderate (6.5%), and severe (1%) forms. Fatal side-effects occurred without exception only in those patients who were severely ill so that any risk of treatment had been fully justified. Among patients with renal failure, malignant haematological diseases or Hodgkin's disease there was a particularly high incidence of side-effects. Although the proportion of the latter patients was only 15% of all in-patients, they accounted for 35% of patients with side-effects.
在1592例患者中，对所有明确的、可能的和疑似的药物副作用进行了为期一年的记录。副作用的严重程度分为轻度（15%）、中度（6.5%）和重度（1%）。致命的副作用无一例外地仅发生在病情严重的患者中，因此任何治疗风险都是完全合理的。在肾衰竭、恶性血液病或霍奇金病患者中，副作用的发生率特别高。尽管后一类患者仅占所有住院患者的15%，但他们却占副作用患者的35%。
