Mattern J, Kaufmann M, Hinderer H, Wayss K, Volm M
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975;83(2):97-104. doi: 10.1007/BF00282976.
Certain substances which influenced nucleic acid metabolism were found to have about the same cytostatic activity on human cells when measured in tissue culture experiments (cell numbers) or in short-term cultures (3-H-uridine incorporation in cell suspensions). By treatment with a dose of cytostatics corresponding to 10 times therapeutic dose, chemosensitive tumors can be distinguished from non-responsive tumors. By using this in vitro test system to investigate the sensitivities of 100 human tumors, it is shown that 28 of these tumors were responsive to adriamycin, daunomycin and Actinomycin D. Good agreement was observed between these in vitro results and the literature data on clinical therapy using these particular substances.
在组织培养实验（细胞数量）或短期培养（细胞悬液中3-H-尿苷掺入）中测定时，发现某些影响核酸代谢的物质对人体细胞具有大致相同的细胞生长抑制活性。通过用相当于治疗剂量10倍的细胞抑制剂剂量进行处理，可以区分化疗敏感肿瘤和无反应肿瘤。利用这个体外测试系统研究100个人类肿瘤的敏感性，结果表明其中28种肿瘤对阿霉素、柔红霉素和放线菌素D有反应。这些体外实验结果与使用这些特定物质进行临床治疗的文献数据之间观察到了良好的一致性。
