Baiyewu O, Unverzagt F W, Ogunniyi A, Hall K S, Gureje O, Gao S, Lane K A, Hendrie H C
Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Eur J Neurol. 2002 Nov;9(6):573-80. doi: 10.1046/j.1468-1331.2002.00434.x.
To determine correlates and outcome of cognitive impairment without dementia in community-dwelling elderly Nigerians. A total of 2487 community residents aged 65 years and over were screened using the Community Screening Interview for Dementia. A subset of 423 individuals received diagnostic clinical evaluation. Participants were diagnosed normal, demented, or cognitive impairment no dementia (CIND). Follow-up clinical diagnostic evaluation was conducted on CIND subjects approximately 2 years later. One hundred and fifty-two persons were diagnosed CIND. Eighty-seven CIND subjects were seen at follow-up assessment, 14 (16.1%) had converted to dementia, 22 (25.3%) reverted to normal, and 51 (58.6%) remained CIND. No baseline factors predicted later development of dementia amongst the CIND subjects. CIND subjects who reverted to normal tended to be male and to have higher baseline cognitive scores. Apolipoprotein status was not related to diagnosis at follow-up. CIND is common in community-dwelling Nigerians. Although the outcome is variable, it does represent a high-risk group for subsequent dementia.
确定尼日利亚社区居住老年人中无痴呆的认知障碍的相关因素及转归情况。使用痴呆症社区筛查访谈对2487名65岁及以上的社区居民进行了筛查。423名个体接受了诊断性临床评估。参与者被诊断为正常、痴呆或无痴呆的认知障碍（CIND）。大约2年后对CIND受试者进行了随访临床诊断评估。152人被诊断为CIND。87名CIND受试者接受了随访评估，其中14人（16.1%）转变为痴呆，22人（25.3%）恢复正常，51人（58.6%）仍为CIND。在CIND受试者中，没有基线因素能预测后期痴呆的发生。恢复正常的CIND受试者往往为男性且基线认知得分较高。载脂蛋白状态与随访时的诊断无关。CIND在尼日利亚社区居住人群中很常见。虽然转归情况各不相同，但它确实代表了随后发生痴呆的高危人群。
