Low L-F, Brodaty H, Edwards R, Kochan N, Draper B, Trollor J, Sachdev P
Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Aust N Z J Psychiatry. 2004 Sep;38(9):725-31. doi: 10.1080/j.1440-1614.2004.01451.x.
To determine the prevalence of "cognitive impairment no dementia" (CIND) and "amnestic mild cognitive impairment" (aMCI) in a population sample of 70-79-year-olds and the risk factors for CIND.
Cross sectional population survey.
Sutherland Shire, Sydney, Australia.
150 community-dwelling 70-79-year-olds were screened by telephone, 42 of whom were assessed at home.
Demographics, subjective ratings of physical and emotional health and memory, cardiovascular risk factors, medications, the Mini-Mental State Examination, Boston Naming Test, Trail Making Tests A and B, Block Design, Rey Auditory Verbal Learning Test (RAVLT), Visual Reproduction, Logical Memory, letter and category fluency, the National Adult Reading Test (NART), the Geriatric Depression Scale (GDS) and the "state" section of the State-Trait Anxiety Inventory (STAI-S).
From the 400 subjects contacted initially, 150 consented to be interviewed and 131 eligible subjects were recruited. Of a 1-in-3 random sample of 42 subjects assessed at home, 14 (33.3%) subjects met criteria for CIND, 1 (2.4%) had possible dementia and the 27 remaining (64.3%) were cognitively normal. Four (9.5%) met criteria for aMCI. Subjects with CIND were older, had lower ranking occupations and were less likely to be currently working than those classified as cognitively normal. Ten subjects with CIND did not meet criteria for aMCI because they lacked subjective memory impairment (n = 3) or had cognitive deficits other than memory (n = 7). All subjects with aMCI met criteria for CIND.
One-third of individuals in this population sample met criteria for CIND. CIND is a broader definition than aMCI. Further research is needed to determine the longitudinal course and clinical utility of these definitions of cognitive impairment.
确定70 - 79岁人群样本中“非痴呆性认知障碍”（CIND）和“遗忘型轻度认知障碍”（aMCI）的患病率以及CIND的危险因素。
横断面人群调查。
澳大利亚悉尼萨瑟兰郡。
通过电话对150名70 - 79岁的社区居民进行筛查，其中42人在家中接受评估。
人口统计学特征、身体和情绪健康及记忆的主观评分、心血管危险因素、药物使用情况、简易精神状态检查表、波士顿命名测试、连线测验A和B、积木图案测试、雷伊听觉词语学习测验（RAVLT）、视觉复制、逻辑记忆、字母流畅性和类别流畅性、国家成人阅读测试（NART）、老年抑郁量表（GDS）以及状态 - 特质焦虑问卷（STAI - S）的“状态”部分。
在最初联系的400名受试者中，150人同意接受访谈，131名符合条件的受试者被招募。在随机抽取的42名在家中接受评估的受试者中，14名（33.3%）符合CIND标准，1名（2.4%）可能患有痴呆症，其余27名（64.3%）认知正常。4名（9.5%）符合aMCI标准。与被归类为认知正常的受试者相比，患有CIND的受试者年龄更大，职业排名更低，且目前工作的可能性更小。10名患有CIND的受试者不符合aMCI标准，因为他们缺乏主观记忆障碍（n = 3）或存在记忆以外的认知缺陷（n = 7）。所有患有aMCI的受试者均符合CIND标准。
该人群样本中有三分之一的个体符合CIND标准。CIND的定义比aMCI更宽泛。需要进一步研究以确定这些认知障碍定义的纵向病程和临床实用性。
