Lathan Monica, Mukasa Leonard Ntaate, Hooper Nancy, Golub Jonathan, Baruch Nancy, Mulcahy Donna, Benjamin William, Cronin Wendy A
Maryland Department of Health and Mental Hygiene, Baltimore, Maryland 21201, USA.
Emerg Infect Dis. 2002 Nov;8(11):1249-51. doi: 10.3201/eid0811.020245.
From 1996 to 2000, 23 Maryland and Washington, D.C., tuberculosis cases were identified in one six-band DNA cluster. Cases were clustered on the basis of their Mycobacterium tuberculosis isolates. Medical record reviews and interviews were conducted to identify epidemiologic linkages. Eighteen (78%) of the 23 case-patients with identical restriction fragment length polymorphism patterns were linked to another member; half the patients were associated with a Washington, D.C., homeless shelter. Molecular epidemiology defined the extent of this large, cross-jurisdictional outbreak.
1996年至2000年期间，在一个六带DNA簇中发现了23例来自马里兰州和华盛顿特区的结核病病例。这些病例是根据结核分枝杆菌分离株进行聚类的。通过查阅病历和访谈来确定流行病学联系。23例具有相同限制性片段长度多态性模式的病例患者中，有18例（78%）与另一名成员有联系；一半的患者与华盛顿特区的一个无家可归者收容所有关联。分子流行病学确定了这起大规模跨辖区疫情的范围。
