Glynn Judith R, Whiteley Jennifer, Bifani Pablo J, Kremer Kristin, van Soolingen Dick
London School of Hygeine and Tropical Medicine, London WC1E 7HT, UK.
Emerg Infect Dis. 2002 Aug;8(8):843-9. doi: 10.3201/eid0805.020002.
Strains of the Beijing/W genotype family of Mycobacterium tuberculosis have caused large outbreaks of tuberculosis, sometimes involving multidrug resistance. This genetically highly conserved family of M. tuberculosis strains predominates in some geographic areas. We have conducted a systematic review of the published reports on these strains to determine their worldwide distribution, spread, and association with drug resistance. Sixteen studies reported prevalence of Beijing strains defined by spoligotyping; another 10 used other definitions. Beijing strains were most prevalent in Asia but were found worldwide. Associations with drug resistance varied: in New York, Cuba, Estonia, and Vietnam, Beijing strains were strongly associated with drug resistance, but elsewhere the association was weak or absent. Although few reports have measured trends in prevalence, the ubiquity of the Beijing strains and their frequent association with outbreaks and drug resistance underline their importance.
结核分枝杆菌北京/W基因型家族的菌株已引发大规模结核病疫情，有时还涉及多重耐药性。这个遗传上高度保守的结核分枝杆菌菌株家族在某些地理区域占主导地位。我们对已发表的关于这些菌株的报告进行了系统综述，以确定它们在全球的分布、传播以及与耐药性的关联。16项研究报告了通过间隔寡核苷酸分型法定义的北京菌株的流行情况；另外10项研究使用了其他定义。北京菌株在亚洲最为普遍，但在世界各地都有发现。与耐药性的关联各不相同：在纽约、古巴、爱沙尼亚和越南，北京菌株与耐药性密切相关，但在其他地方这种关联较弱或不存在。尽管很少有报告测量流行趋势，但北京菌株的广泛存在及其与疫情和耐药性的频繁关联凸显了它们的重要性。
