Carlsson Annelie K, Lindberg Bengt A, Bredberg Anders C A, Hyöty Heikki, Ivarsson Sten-A
Department of Pediatrics, University of Lund, University Hospital, Malmö, Sweden.
J Pediatr Gastroenterol Nutr. 2002 Nov;35(5):649-52. doi: 10.1097/00005176-200211000-00011.
There is a strong genetic influence on the susceptibility to celiac disease but it is also evident that environmental factors play a role in the development of the disease. Diverging studies about adenovirus infection as a possible triggering factor in the pathogenesis have been reported. Our study was undertaken to determine whether enterovirus infection during pregnancy is a risk factor for the development of celiac disease later in childhood.
Cord blood from 76 mothers whose children developed celiac disease before 15 years of age were analyzed for IgA, IgG, and IgM antibodies for enteroviruses and Ig-A endomysium antibodies. The control group comprised cord blood from 327 mothers with children without known celiac disease.
There were no significant differences in antibody titers for enterovirus between the two groups. IgA-endomysium antibodies were elevated in 3 of the 76 mothers, whereas none had known celiac disease.
This study does not show that enterovirus infection during pregnancy is associated with the development of celiac disease in childhood. Of the mothers whose children developed celiac disease, 4% had Ig-A endomysium antibodies, which may reflect a silent celiac disease.
乳糜泻易感性受强大的遗传影响，但环境因素在该疾病发展中起作用也很明显。关于腺病毒感染作为发病机制中可能触发因素的研究结果不一。我们开展这项研究以确定孕期肠道病毒感染是否是儿童后期患乳糜泻的危险因素。
对76名15岁前孩子患乳糜泻的母亲的脐带血进行分析，检测肠道病毒的IgA、IgG和IgM抗体以及IgA-内肌层抗体。对照组包括327名孩子无乳糜泻的母亲的脐带血。
两组之间肠道病毒抗体滴度无显著差异。76名母亲中有3名IgA-内肌层抗体升高，而她们均无已知的乳糜泻。
这项研究未表明孕期肠道病毒感染与儿童期乳糜泻的发生有关。在孩子患乳糜泻的母亲中，4%有IgA-内肌层抗体，这可能反映了无症状的乳糜泻。
