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1
Glycine-specific synapses in rat spinal cord. Identification by electron microscope autoradiography.大鼠脊髓中甘氨酸特异性突触。通过电子显微镜放射自显影鉴定。
J Cell Biol. 1976 Feb;68(2):389-95. doi: 10.1083/jcb.68.2.389.
2
Neuronal uptake of [3H]GABA and [3H]glycine in laminae I-III (substantia gelatinosa Rolandi) of the rat spinal cord. An autoradiographic study.大鼠脊髓I-III层（罗蓝氏胶状质）中[3H]γ-氨基丁酸和[3H]甘氨酸的神经元摄取：放射自显影研究
Brain Res. 1980 Apr 28;188(2):449-64. doi: 10.1016/0006-8993(80)90044-x.
3
An electron microscope study of glycine-like immunoreactivity in laminae I-III of the spinal dorsal horn of the rat.
Neuroscience. 1990;39(2):387-94. doi: 10.1016/0306-4522(90)90275-9.
4
Immunocytochemical localization of glycine in the lamprey spinal cord with reference to GABAergic and glutamatergic synapses: a light and electron microscopic study.参照γ-氨基丁酸能和谷氨酸能突触，对七鳃鳗脊髓中甘氨酸进行免疫细胞化学定位：光镜和电镜研究
Acta Biol Hung. 1996;47(1-4):393-410.
5
GABA and glycine in synaptic glomeruli of the rat spinal dorsal horn.大鼠脊髓背角突触小球中的γ-氨基丁酸和甘氨酸
Eur J Neurosci. 1996 Dec;8(12):2492-8. doi: 10.1111/j.1460-9568.1996.tb01543.x.
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Immunocytochemical localization of tetanus toxin to synapses of spinal cord.
Neurosci Lett. 1981 May 6;23(2):149-55. doi: 10.1016/0304-3940(81)90032-x.
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[Ultrastructural features of gap junction type synapses in the motor nuclei of the frog spinal cord].
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[Gaba- and glycine-immunoreactive synapses in the spinal cord of the frog Rana temporaria].[泽蛙脊髓中γ-氨基丁酸和甘氨酸免疫反应性突触]
Tsitologiia. 2010;52(7):537-48.

引用本文的文献

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Early history of glycine receptor biology in Mammalian spinal cord circuits.脊椎回路中甘氨酸受体生物学的早期历史。
Front Mol Neurosci. 2010 May 21;3:13. doi: 10.3389/fnmol.2010.00013. eCollection 2010.
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Chloride influx aggravates Ca2+-dependent AMPA receptor-mediated motoneuron death.氯离子内流会加重钙离子依赖性AMPA受体介导的运动神经元死亡。
J Neurosci. 2003 Jun 15;23(12):4942-50. doi: 10.1523/JNEUROSCI.23-12-04942.2003.
3
The uptake and release of [3H]glycine in the goldfish retina.[3H]甘氨酸在金鱼视网膜中的摄取与释放
J Physiol. 1980 Nov;308:185-95. doi: 10.1113/jphysiol.1980.sp013467.
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Glycine-like immunoreactivity in the cerebellum of rat and Senegalese baboon, Papio papio: a comparison with the distribution of GABA-like immunoreactivity and with [3H]glycine and [3H]GABA uptake.
Exp Brain Res. 1987;66(1):211-21. doi: 10.1007/BF00236216.
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Quantitative electron microscopic immunocytochemistry of neuroactive amino acids.神经活性氨基酸的定量电子显微镜免疫细胞化学
Anat Embryol (Berl). 1989;180(1):1-15. doi: 10.1007/BF00321895.

本文引用的文献

1
The time courses of excitatory and inhibitory synaptic actions.兴奋性和抑制性突触作用的时间进程。
J Physiol. 1959 Mar 12;145(3):529-46. doi: 10.1113/jphysiol.1959.sp006159.
2
Uptake of 14C glycine by spinal cord.脊髓对14C甘氨酸的摄取
Nature. 1969 May 17;222(5194):679-80. doi: 10.1038/222679a0.
3
The hyperpolarization of spinal motoneurones by glycine and related amino acids.甘氨酸及相关氨基酸对脊髓运动神经元的超极化作用。
Exp Brain Res. 1968;5(3):235-58. doi: 10.1007/BF00238666.
4
The uptake of [14C]glycine by slices of mammalian spinal cord.[14C]甘氨酸被哺乳动物脊髓切片摄取的情况。
J Physiol. 1971 May;215(1):103-17. doi: 10.1113/jphysiol.1971.sp009460.
5
Spatial synaptic distribution of recurrent and group Ia inhibitory systems in cat spinal motoneurones.猫脊髓运动神经元中回返性和Ia类群抑制系统的空间突触分布
J Physiol. 1971 Apr;214(2):305-26. doi: 10.1113/jphysiol.1971.sp009434.
6
Localization of the sites of gamma-aminobutyric acid (GABA) uptake in lobster nerve-muscle preparations.龙虾神经-肌肉制剂中γ-氨基丁酸（GABA）摄取位点的定位。
J Cell Biol. 1971 Apr;49(1):75-89. doi: 10.1083/jcb.49.1.75.
7
Studies of the uptake of 3 H-gaba and ( 3 H)glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography.通过电子显微镜放射自显影术对大鼠脑和脊髓切片及匀浆中³H-γ-氨基丁酸和（³H）甘氨酸摄取的研究。
Brain Res. 1972 Jun 8;41(1):131-43. doi: 10.1016/0006-8993(72)90621-x.
8
Autoradiographic uptake patterns of (3H)GABA and (3H)glycine in central nervous tissues with special reference to the cat spinal cord.（3H）γ-氨基丁酸和（3H）甘氨酸在中枢神经组织中的放射自显影摄取模式，特别提及猫脊髓。
Brain Res. 1973 Nov 23;62(2):587-95. doi: 10.1016/0006-8993(73)90726-9.
9
An autoradiographic study of uptake of exogenous glycine by vertebrate spinal cord splices in vitro.脊椎动物脊髓切片体外摄取外源性甘氨酸的放射自显影研究。
J Neurocytol. 1972 Jul;1(1):27-34. doi: 10.1007/BF01098643.
10
Specific glycine--accumulating synaptosomes in the spinal cord of rats.大鼠脊髓中特异性积累甘氨酸的突触小体。
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3485-9. doi: 10.1073/pnas.69.11.3485.

大鼠脊髓中甘氨酸特异性突触。通过电子显微镜放射自显影鉴定。

Glycine-specific synapses in rat spinal cord. Identification by electron microscope autoradiography.

作者信息

Price D L, Stocks A, Griffin J W, Young A, Peck K

出版信息

J Cell Biol. 1976 Feb;68(2):389-95. doi: 10.1083/jcb.68.2.389.

DOI:10.1083/jcb.68.2.389
PMID:1245552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2109627/
Abstract

Glycine, an inhibitory transmitter in spinal cord, is taken up into specific nerve terminals by means of a unique high-affinity uptake system. In this study, [3H]glycine was directly microinjected into rat ventral horn in vivo and electron microscope autoradiography used to localize the label in various anatomic compartments. Quantiative analysis showed that [3H]glycine labeled a high proportion of axosomatic and axodendritic synapses which presumably act to inhibit spinal motor neurons.

摘要

甘氨酸是脊髓中的一种抑制性递质，它通过一种独特的高亲和力摄取系统被摄取到特定的神经末梢中。在本研究中，将[3H]甘氨酸直接活体微量注射到大鼠腹角，并使用电子显微镜放射自显影术将标记定位在各种解剖区域。定量分析表明，[3H]甘氨酸标记了很大比例的轴体突触和轴树突触，这些突触可能起到抑制脊髓运动神经元的作用。