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本文引用的文献

1
Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region.S-腺苷-L-甲硫氨酸对人胱硫醚β-合酶的调节作用：涉及C端区域自抑制结构域的两种催化活性构象的证据。
Biochemistry. 2001 Sep 4;40(35):10625-33. doi: 10.1021/bi010711p.
2
Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein.人胱硫醚β-合酶的结构：一种独特的依赖于磷酸吡哆醛的血红素蛋白。
EMBO J. 2001 Aug 1;20(15):3910-6. doi: 10.1093/emboj/20.15.3910.
3
Regions of microsynteny in Magnaporthe grisea and Neurospora crassa.稻瘟病菌和粗糙脉孢菌中的微共线性区域。
Fungal Genet Biol. 2001 Jul;33(2):137-43. doi: 10.1006/fgbi.2001.1286.
4
Gene discovery and gene function assignment in filamentous fungi.丝状真菌中的基因发现与基因功能确定
Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5110-5. doi: 10.1073/pnas.091094198. Epub 2001 Apr 10.
5
Transsulfuration in Saccharomyces cerevisiae is not dependent on heme: purification and characterization of recombinant yeast cystathionine beta-synthase.酿酒酵母中的转硫作用不依赖于血红素：重组酵母胱硫醚β-合酶的纯化与特性分析
J Inorg Biochem. 2000 Aug 31;81(3):161-71. doi: 10.1016/s0162-0134(00)00100-8.
6
Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein.
J Biol Chem. 2000 Apr 21;275(16):11541-4. doi: 10.1074/jbc.c000056200.
7
Homocysteine.同型半胱氨酸
Int J Biochem Cell Biol. 2000 Apr;32(4):385-9. doi: 10.1016/s1357-2725(99)00138-7.
8
Strategies for the treatment of cystathionine beta-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years.胱硫醚β-合酶缺乏症的治疗策略：威林克生化遗传学研究室过去30年的经验
Eur J Pediatr. 1998 Apr;157 Suppl 2:S71-6. doi: 10.1007/pl00014308.
9
Molecular genetics of sulfur assimilation in filamentous fungi and yeast.丝状真菌和酵母中硫同化的分子遗传学
Annu Rev Microbiol. 1997;51:73-96. doi: 10.1146/annurev.micro.51.1.73.
10
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.空位BLAST和位置特异性迭代BLAST：新一代蛋白质数据库搜索程序。
Nucleic Acids Res. 1997 Sep 1;25(17):3389-402. doi: 10.1093/nar/25.17.3389.

稻瘟病菌中胱硫醚β-合酶基因CBS1的分子特征分析

Molecular characterization of a cystathionine beta-synthase gene, CBS1, in Magnaporthe grisea.

作者信息

Lo Sze Chung Clive, Hamer Lisbeth, Hamer John E

机构信息

Microbial Research, Paradigm Genetics, Inc., Research Triangle Park, North Carolina 27709, USA.

出版信息

Eukaryot Cell. 2002 Apr;1(2):311-4. doi: 10.1128/EC.1.2.311-314.2002.

DOI:10.1128/EC.1.2.311-314.2002
PMID:12455965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC118034/
Abstract

CBS1 from Magnaporthe grisea is a structural and functional homolog of the cystathionine beta-synthase (CBS) gene from Saccharomyces cerevisiae. Our studies indicated that M. grisea can utilize homocysteine and methionine through a CBS-independent pathway. The results also revealed responses of M. grisea to homocysteine that are reminiscent of human homocystinuria.

摘要

稻瘟病菌的CBS1是酿酒酵母中胱硫醚β-合酶（CBS）基因的结构和功能同源物。我们的研究表明，稻瘟病菌可以通过一条不依赖CBS的途径利用同型半胱氨酸和甲硫氨酸。结果还揭示了稻瘟病菌对同型半胱氨酸的反应，这让人联想到人类的同型胱氨酸尿症。