Celedón Juan C, Litonjua Augusto A, Ryan Louise, Weiss Scott T, Gold Diane R
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Pediatrics. 2002 Dec;110(6):e77. doi: 10.1542/peds.110.6.e77.
Bottle feeding in the bed or crib before sleep time has been associated with an increased risk of wheezing in the first year of life. We examined whether bottle feeding in the bed or crib before sleep time in the first year of life is associated with wheezing in the first 5 years of life.
In a prospective cohort study of 448 children with parental history of atopy followed from birth, we examined the relation between the number of bimonthly parental reports of bottle feeding in the bed or crib before sleep time in the first year of life (range: 0-6 reports) and parental report of wheezing in the first 5 years of life. Additional outcome measures included recurrent wheezing (> or =2 episodes of wheezing in the previous year) and asthma (physician-diagnosed asthma and > or =1 episode of wheezing in the previous year) at the age of 5 years.
The risk of recurrent wheezing and asthma at 5 years of age increased significantly with each additional report of bottle feeding in the bed or crib before sleep time in the first year of life. The risk of wheezing between the ages of 1 and 5 years increased with each additional report of bottle feeding in the bed or crib before sleep time in the first year of life. As an example, a child whose parents reported bottle feeding in the bed or crib before sleep time on 3 occasions in the first year of life had 1.5 times higher risk of wheezing between the ages of 1 and 5 years than a child whose parents did not report bottle feeding in the bed or crib before sleep time in the first year of life (95% confidence interval for relative risk: 1.12-2.12).
Among children with parental history of atopy, bottle feeding in the bed or crib before sleep time in the first year of life is a risk factor for recurrent wheezing and asthma at 5 years of age and a risk factor for wheezing between the ages of 1 and 5 years.
睡前在床上或婴儿床中用奶瓶喂养与1岁以内喘息风险增加有关。我们研究了1岁以内睡前在床上或婴儿床中用奶瓶喂养是否与5岁以内喘息有关。
在一项对448名有特应性疾病家族史的儿童从出生起进行随访的前瞻性队列研究中，我们研究了1岁以内父母每两个月报告的睡前在床上或婴儿床中用奶瓶喂养次数（范围：0至6次报告）与5岁以内父母报告的喘息之间的关系。其他结局指标包括5岁时反复喘息（前一年≥2次喘息发作）和哮喘（医生诊断的哮喘且前一年≥1次喘息发作）。
1岁以内每增加一次睡前在床上或婴儿床中用奶瓶喂养的报告，5岁时反复喘息和哮喘的风险就显著增加。1岁至5岁之间喘息的风险随着1岁以内每增加一次睡前在床上或婴儿床中用奶瓶喂养的报告而增加。例如，父母报告1岁以内孩子有3次睡前在床上或婴儿床中用奶瓶喂养的儿童，1至5岁之间喘息的风险是父母未报告1岁以内孩子有睡前在床上或婴儿床中用奶瓶喂养的儿童的1.5倍（相对风险的95%置信区间：1.12至2.12）。
在有特应性疾病家族史的儿童中，1岁以内睡前在床上或婴儿床中用奶瓶喂养是5岁时反复喘息和哮喘的危险因素，也是1至5岁之间喘息的危险因素。
