Boulon Séverine, Basyuk Eugenia, Blanchard Jean Marie, Bertrand Edouard, Verheggen Céline
IGMM-CNRS UMR 5535, IFR24, 1919, route de Mende, 34293 Montpellier cedex 5, France.
Biochimie. 2002 Aug;84(8):805-13. doi: 10.1016/s0300-9084(02)01438-4.
Despite recent advances, the mechanisms of RNA movements and targeting within the nucleus are still mysterious. While diffusion appears to play a crucial role in nuclear dynamics and RNA transport, some data argue for a model in which diffusion is controlled, at least in part, by the organization of the nucleus in well-defined compartments. Much of the recent progress is based on imaging technologies, and this review will first present them in some detail. We will then summarize studies that analyzed nuclear movements of both polyadenylated RNA and box C/D snoRNP. Indeed, this latter model has already brought a number of interesting results. We will finally present some of our original results on box C/D snoRNA transport.
尽管最近取得了进展，但RNA在细胞核内的移动和靶向机制仍然神秘莫测。虽然扩散似乎在核动力学和RNA运输中起着关键作用，但一些数据支持这样一种模型，即扩散至少部分地受到细胞核中明确界定的区室组织的控制。最近的许多进展都基于成像技术，本综述将首先详细介绍这些技术。然后，我们将总结分析多聚腺苷酸化RNA和C/D盒小核仁核糖核蛋白（box C/D snoRNP）核移动的研究。事实上，后一种模型已经带来了许多有趣的结果。最后，我们将展示一些关于C/D盒小核仁RNA（box C/D snoRNA）运输的原始结果。
