Chen Kang, Aradi Ildiko, Santhakumar Vijayalakshmi, Soltesz Ivan
Dept of Anatomy & Neurobiology, University of California Irvine, 92697-1280, USA.
Trends Pharmacol Sci. 2002 Dec;23(12):552-7. doi: 10.1016/s0165-6147(02)02110-7.
Hyperpolarization-activated cation channels (h-channels) are key regulators of neuronal excitation and inhibition, and have a rich diversity of subunit composition, distribution, modulation and function. Recent results indicate that the behavior of h-channels can be altered significantly by seizures. The activity-dependent, short-term and long-term plasticity of h-channels can, in turn, modulate neuronal excitability. The reciprocal interactions between neuronal activity and h-channels indicate that these ion channels could be promising novel targets for anti-epileptic therapies.
超极化激活阳离子通道（h通道）是神经元兴奋和抑制的关键调节因子，其亚基组成、分布、调节和功能具有丰富的多样性。最近的研究结果表明，癫痫发作可显著改变h通道的行为。反过来，h通道的活动依赖性短期和长期可塑性可调节神经元兴奋性。神经元活动与h通道之间的相互作用表明，这些离子通道可能是抗癫痫治疗有前景的新靶点。
