H通道的多重特性
The multiple personalities of h-channels.
作者信息
Santoro Bina, Baram Tallie Z
机构信息
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.
出版信息
Trends Neurosci. 2003 Oct;26(10):550-4. doi: 10.1016/j.tins.2003.08.003.
Abstract
Concepts regarding the function of the hyperpolarization-activated current (Ih) in shaping the excitability of single cells and neuronal ensembles have been evolving rapidly following the recent cloning of genes that encode the underlying 'h-channels' - the HCN genes. This article reviews new information about the transcriptional regulation of these channels, highlighting novel studies that demonstrate short- and long-term modulation of HCN expression, and linking this modulation to mechanisms of neurological diseases.
摘要
随着最近编码潜在“h通道”的基因——HCN基因的克隆，关于超极化激活电流（Ih）在塑造单细胞和神经元群体兴奋性方面功能的概念一直在迅速演变。本文综述了有关这些通道转录调控的新信息，重点介绍了一些新研究，这些研究证明了HCN表达的短期和长期调节，并将这种调节与神经疾病机制联系起来。
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Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.人类和实验性癫痫海马体中存活的齿状回颗粒细胞中特定超极化激活环核苷酸门控阳离子通道（HCN）的表达增强。
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