Santoro Bina, Baram Tallie Z
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.
Trends Neurosci. 2003 Oct;26(10):550-4. doi: 10.1016/j.tins.2003.08.003.
Concepts regarding the function of the hyperpolarization-activated current (Ih) in shaping the excitability of single cells and neuronal ensembles have been evolving rapidly following the recent cloning of genes that encode the underlying 'h-channels' - the HCN genes. This article reviews new information about the transcriptional regulation of these channels, highlighting novel studies that demonstrate short- and long-term modulation of HCN expression, and linking this modulation to mechanisms of neurological diseases.
随着最近编码潜在“h通道”的基因——HCN基因的克隆，关于超极化激活电流（Ih）在塑造单细胞和神经元群体兴奋性方面功能的概念一直在迅速演变。本文综述了有关这些通道转录调控的新信息，重点介绍了一些新研究，这些研究证明了HCN表达的短期和长期调节，并将这种调节与神经疾病机制联系起来。
