Kocamis H, Killefer J
Division of Histology and Embryology, Veterinary Faculty, Kafkas University, Kars 36200, Turkey.
Domest Anim Endocrinol. 2002 Nov;23(4):447-54. doi: 10.1016/s0739-7240(02)00178-9.
Myostatin (also known as growth/differentiation factor-8) is a recently identified member of the transforming growth factor-beta family of secreted regulatory factors. Mice having targeted disruption of the myostatin gene displayed a marked increase in muscle mass, up to three times normal size. Additionally, a myostatin mutation has been linked to double muscled cattle breeds characterized by a visible, generalized increase in muscle mass. Therefore, it is suggested that myostatin in muscle may be one of the long sought inhibitors that specifically control the growth of individual tissues or organs. In the present paper, we review involvement of myostatin in muscle growth of different species.
肌肉生长抑制素（也称为生长/分化因子-8）是最近发现的转化生长因子-β家族分泌调节因子的成员。肌肉生长抑制素基因被靶向破坏的小鼠肌肉量显著增加，达到正常大小的三倍。此外，肌肉生长抑制素突变与双肌牛品种有关，其特征是肌肉量明显普遍增加。因此，有人提出肌肉中的肌肉生长抑制素可能是长期以来寻找的特异性控制单个组织或器官生长的抑制剂之一。在本文中，我们综述了肌肉生长抑制素在不同物种肌肉生长中的作用。
