Bourassa Nancy, Major François
Département de biochimie, Université de Montréal, Québec, Canada.
Biochimie. 2002 Sep;84(9):945-51. doi: 10.1016/s0300-9084(02)01444-x.
RNA is an important component of many biological processes, including DNA encapsidation of bacteriophage phi29 of Bacillus subtilis. Interestingly, the prohead RNA is involved in this encapsidation, and was found in monomer, dimer, pentamer and hexamer conformations. This article presents and debates current knowledge about the prohead RNA structures, mechanisms, and roles in DNA encapsidation. A new dimer structure is presented, and its specific role in DNA encapsidation is discussed.
RNA是许多生物过程的重要组成部分，包括枯草芽孢杆菌噬菌体phi29的DNA衣壳化过程。有趣的是，前头部RNA参与了这一衣壳化过程，并发现其存在单体、二聚体、五聚体和六聚体构象。本文介绍并讨论了当前关于前头部RNA结构、机制及其在DNA衣壳化中作用的知识。文中提出了一种新的二聚体结构，并讨论了其在DNA衣壳化中的具体作用。
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