六聚体RNA在体外噬菌体φ29 DNA包装中的作用
Function of hexameric RNA in packaging of bacteriophage phi 29 DNA in vitro.
作者信息
Zhang F, Lemieux S, Wu X, St-Arnaud D, McMurray C T, Major F, Anderson D
机构信息
Department of Genetics and Cell Biology, University of Minnesota, Minneapolis 55455, USA.
出版信息
Mol Cell. 1998 Jul;2(1):141-7. doi: 10.1016/s1097-2765(00)80123-9.
A cyclic hexamer of the 120-base prohead RNA (pRNA) is needed for efficient in vitro packaging of the B. subtilis bacteriophage phi 29 genome. This capacity of pRNA to form higher multimers by intermolecular base pairing of identical subunits represents a new RNA structural motif. Dimers of pRNA are likely intermediates in formation of the cyclic hexamer. A three-dimensional model of the pRNA hexamer is presented.
枯草芽孢杆菌噬菌体phi 29基因组的高效体外包装需要120个碱基的原头部RNA（pRNA）形成环状六聚体。pRNA通过相同亚基的分子间碱基配对形成更高阶多聚体的这种能力代表了一种新的RNA结构基序。pRNA二聚体可能是环状六聚体形成过程中的中间体。本文展示了pRNA六聚体的三维模型。
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