Akata Filiz, Oztürk Devrim, Tansel Ozlem, Tatman-Otkun Müserref, Otkun Metin, Fitoussi Frederic, Bingen Edouard, Tugrul Murat
Department of Clinical Bacteriology and Infectious Diseases, Medical Faculty of Trakya University, 22030 Edirne, Turkey.
Int J Antimicrob Agents. 2002 Dec;20(6):461-3. doi: 10.1016/s0924-8579(02)00241-8.
The aim of this study was to determine the susceptibilities to macrolides of Group A streptococcal isolates from the European section of Turkey. In the case of resistant isolates, the patterns and genetic mechanisms of erythromycin resistance were studied. Seven (2.7%) of the 260 isolates were resistant to erythromycin. Four of them showed the M phenotype and harboured mefA genes whereas three isolates showed the inducible macrolide, lincosamide and streptogramin B resistance phenotype and harboured ermTR genes. In the European section of Turkey, the current resistance rate of Group A streptococci to macrolides remains low.
本研究的目的是确定来自土耳其欧洲部分的A组链球菌分离株对大环内酯类药物的敏感性。对于耐药分离株，研究了红霉素耐药的模式和遗传机制。260株分离株中有7株（2.7%）对红霉素耐药。其中4株表现为M表型并携带mefA基因，而3株分离株表现出诱导型大环内酯类、林可酰胺类和链阳菌素B耐药表型并携带ermTR基因。在土耳其欧洲部分，A组链球菌目前对大环内酯类药物的耐药率仍然较低。
