Kataja J, Huovinen P, Seppälä H
Antimicrobial Research Laboratory, National Public Health Institute, PO Box 57, 20521 Turku, Finland.
J Antimicrob Chemother. 2000 Nov;46(5):789-92. doi: 10.1093/jac/46.5.789.
A total of 238 erythromycin-resistant Streptococcus pyogenes isolates were collected in 1986-1997 from eight different countries in Europe and North and South America. The antibiotic susceptibility patterns of all isolates and the resistance genes of 92 isolates of known clonal origin were studied. The mefA gene was detected in all 54 isolates with the M-phenotype and was found in every country. The ermTR and the ermB genes were detected in 27 and 11, respectively, of the 38 isolates with the macrolide-lincosamide-streptogramin B resistance phenotypes. In addition to the mefA gene, the recently sequenced ermTR gene was also widely distributed among isolates of different clonal origin.
1986年至1997年期间，从欧洲、南北美洲的八个不同国家共收集了238株耐红霉素的化脓性链球菌分离株。研究了所有分离株的抗生素敏感性模式以及92株已知克隆来源分离株的耐药基因。在所有54株具有M表型的分离株中均检测到mefA基因，且在每个国家都有发现。在38株具有大环内酯-林可酰胺-链阳菌素B耐药表型的分离株中，分别检测到27株和11株含有ermTR和ermB基因。除mefA基因外，最近测序的ermTR基因也广泛分布于不同克隆来源的分离株中。
