Lange W, Schöttler M
Brentanostrasse 26, 12163 Berlin, Germany.
Med Microbiol Immunol. 2002 Dec;191(3-4):139-44. doi: 10.1007/s00430-002-0133-2. Epub 2002 Sep 14.
Real-time surveillance information is the prerequisite for accurate influenza diagnosis followed by appropriate treatment of acute influenza with neuraminidase inhibitors. With REALFLU trade mark Surveillance, Hoffmann-La Roche has developed an international early warning system for influenza. The feasibility of the newly developed real-time influenza surveillance in Germany was tested and the results were compared with those of the established German influenza sentinel system of Influenza Study Group (Arbeitsgemeinschaft Influenza, AGI). The evaluation of the REALFLU trade mark Surveillance was performed during the winters of 1999/2000 and 2000/2001. The percentage of influenza-like illnesses among patients seen by the reporting physicians and positives of the Roche Influenza A/B Rapid Test were reported daily by internet, evaluated and could be called up on dynamic internet web pages real-time. The group of project participants could at any time call up the evaluations of the current data on password-protected internet web pages. A retrospective comparison with data obtained by the AGI showed good agreement between the two systems. Even better agreement was obtained on comparing the data with the virus isolates of the National Reference Centers (NRZ). This confirms the reliability of the selected methodology. REALFLU trade mark Surveillance provided information about influenza outbreaks 1-2 weeks earlier than NRZ and the AGI. The results show that it is possible and reasonable to conduct influenza surveillance on a real-time basis. In an overall context of REALFLU trade mark Surveillance, the German pilot project was capable of reflecting the influenza situation on a real-time and regionalized basis during both winters. The Roche Influenza A/B Rapid test proved to be a useful surveillance tool.
实时监测信息是准确诊断流感并随后用神经氨酸酶抑制剂对急性流感进行适当治疗的前提条件。通过“REALFLU”商标监测，罗氏公司开发了一种流感国际预警系统。对德国新开发的实时流感监测的可行性进行了测试，并将结果与德国流感研究小组（Arbeitsgemeinschaft Influenza，AGI）已建立的流感哨点系统的结果进行了比较。“REALFLU”商标监测的评估在1999/2000年和2000/2001年冬季进行。报告医生诊治的患者中流感样疾病的百分比以及罗氏甲型/乙型流感快速检测的阳性结果通过互联网每日上报、评估，并可在动态互联网网页上实时调用。项目参与小组可随时在受密码保护的互联网网页上调用当前数据的评估结果。与AGI获得的数据进行回顾性比较显示，两个系统之间具有良好的一致性。将数据与国家参考中心（NRZ）的病毒分离株进行比较时，一致性更好。这证实了所选方法的可靠性。“REALFLU”商标监测比NRZ和AGI提前1 - 2周提供流感暴发信息。结果表明，实时进行流感监测是可行且合理的。在“REALFLU”商标监测的整体背景下，德国试点项目能够在两个冬季实时且按区域反映流感情况。罗氏甲型/乙型流感快速检测被证明是一种有用的监测工具。
