多巴胺-β-羟化酶抑制对猫脑血管痉挛的影响。
Effect of dopamine-beta-hydroxylase inhibition on cerebral vasospasm in the cat.
作者信息
Battista A F, Flamm E S, Goldstein M, Freedman L S
出版信息
J Neurosurg. 1976 Feb;44(2):168-72. doi: 10.3171/jns.1976.44.2.0168.
PMID:1245859
Abstract
Inhibitors of dopamine beta hydroxylase (DBH) administered intraperitoneally were shown to prevent spasm of the basilar artery caused by blood application in cats. A low or nondetectable blood DBH activity level may be related to the absence of spasm. In several instances, however, moderate spasm did occur with a low blood DBH activity level. Possible mechanisms for these findings are discussed.
摘要
经腹腔注射的多巴胺β羟化酶（DBH）抑制剂可预防猫因注入血液而引起的基底动脉痉挛。血液中DBH活性水平较低或无法检测到可能与无痉挛现象有关。然而，在一些情况下，血液中DBH活性水平较低时仍会出现中度痉挛。本文讨论了这些发现的可能机制。
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