Bhandari Uma, Kanojia Raman, Pillai K K
Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi, India.
Int J Exp Diabetes Res. 2002 Jul-Sep;3(3):159-62. doi: 10.1080/15604280214278.
Diabetes mellitus has been treated orally with herbal remedies based on folk medicine since ancient times. Embelia ribes burm (Myrsinaceae), known commonly as vidanga, was used in Ayurveda for its anthelmintic activity. Ayurveda describes vidanga as pungent, causes increase in digestive fire, and cures flatulence and colic. A single study reported the antihyperglycemic activity of decoction of E. ribes in glucose-induced hyperglycemic albino rabbits. In the present study, the lipid-lowering and antioxidant potential of ethanolic extract of E. ribes burm was investigated in streptozotocin (40 mg/kg, IV, single injection)-induced diabetes in rats. Twenty days of orally feeding the extract (200 mg/kg) to diabetic rats resulted in significant (P < 0.01) decrease in blood glucose, serum total cholesterol, and triglycerides, and increase in HDL-cholesterol levels when compared to pathogenic diabetic rats. Further, the extract also lowered the liver and pancreas thiobarbituric acid-reactive substances (TBARSs) values (P < 0.01) when compared to TBARS values of liver and pancreas of pathogenic diabetic rats. The results of test drug were comparable to gliclazide (25 mg/kg, orally), a standard antihyperglycemic agent. This is the first pilot study to provide biochemical evidence of potential of E. ribes in diabetic dyslipidemia.
自古以来，糖尿病就一直通过基于民间医学的草药进行口服治疗。紫金牛（紫金牛科），通常被称为印度防己，在阿育吠陀医学中因其驱虫活性而被使用。阿育吠陀医学将印度防己描述为辛辣味，可增强消化之火，并治愈肠胃胀气和绞痛。一项研究报告了紫金牛水煎剂对葡萄糖诱导的高血糖白化兔的降血糖活性。在本研究中，研究了紫金牛乙醇提取物对链脲佐菌素（40 mg/kg，静脉注射，单次注射）诱导的大鼠糖尿病的降脂和抗氧化潜力。与致病糖尿病大鼠相比，给糖尿病大鼠口服提取物（200 mg/kg）20天导致血糖、血清总胆固醇和甘油三酯显著（P < 0.01）降低，高密度脂蛋白胆固醇水平升高。此外，与致病糖尿病大鼠肝脏和胰腺的硫代巴比妥酸反应性物质（TBARS）值相比，提取物还降低了肝脏和胰腺的TBARS值（P < 0.01）。受试药物的结果与标准抗高血糖药物格列齐特（25 mg/kg，口服）相当。这是第一项提供紫金牛在糖尿病血脂异常方面潜力的生化证据的初步研究。
