Mora J, Aguilera V, Sala T, Martínez F, Bastida G, Palau A, Argüello L, Pons V, Pertejo V, Berenguer J, Alapont J M
Unidad de Endoscopias. Servicios de Medicina Digestiva. Hospital La Fe. Valencia. España.
Gastroenterol Hepatol. 2002 Dec;25(10):585-8. doi: 10.1016/s0210-5705(02)70320-8.
The aim of this study was to determine the safety and effectiveness of extracorporeal shock wave lithotripsy (ESWL) in difficult bile duct stones resistant to endoscopic extraction.
From January 1997 to February 2002, combined treatment with endoscopy and ESWL was used in 19 patients who had undergone unsuccessful endoscopic bile duct stone extraction after sphincterotomy. The procedure was carried out using analgesic and sedative drugs or deep sedation, prophylactic antibiotic therapy, and monitoring of vital signs. Bile duct stone localization was performed by contrast injection through nasobiliary drainage and fluoroscopy. After each ESWL session, lavage was performed through drainage and stone fragments were extracted endoscopically.
The 19 patients presented high surgical risk due to advanced aged and/or concomitant diseases. All presented jaundice and pain and nine (47.3%) presented associated cholangitis. Thirty ESWL sessions were performed (1.57 sessions per patient), with a mean of 2,120 shock waves per session. In 16 of the 19 patients (84.2%), combined treatment with ESWL and subsequent instrumental endoscopic extraction achieved complete clearance of the biliary tract. The treatment failed in 3 patients who were referred for surgical treatment. No early or late complications were observed, except in one patient who presented a self-limiting febrile syndrome.
Therapeutic endoscopy combined with ESWL is safe and effective in patients with difficult bile duct stones. It represents a therapeutic alternative in patients at high surgical risk.
本研究旨在确定体外冲击波碎石术(ESWL)治疗内镜下难以取出的胆管结石的安全性和有效性。
1997年1月至2002年2月,对19例在括约肌切开术后内镜下胆管结石取出失败的患者采用内镜与ESWL联合治疗。手术在使用镇痛和镇静药物或深度镇静、预防性抗生素治疗以及生命体征监测下进行。通过经鼻胆管引流造影和荧光透视进行胆管结石定位。每次ESWL治疗后,通过引流进行冲洗,并经内镜取出结石碎片。
19例患者因高龄和/或合并疾病而手术风险高。所有患者均有黄疸和疼痛,9例(47.3%)合并胆管炎。共进行了30次ESWL治疗(每位患者平均1.57次),每次平均2120次冲击波。19例患者中的16例(84.2%)通过ESWL联合后续器械内镜取出实现了胆道结石的完全清除。3例患者治疗失败,转至外科手术治疗。除1例出现自限性发热综合征的患者外,未观察到早期或晚期并发症。
治疗性内镜联合ESWL治疗难治性胆管结石患者安全有效。它为手术风险高的患者提供了一种治疗选择。