Kovala-Demertzi Dimitra, Demertzis Mavroudis A, Miller John R, Frampton Christopher S, Jasinski Jerry P, West Douglas X
Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
J Inorg Biochem. 2002 Nov 11;92(2):137-40. doi: 10.1016/s0162-0134(02)00493-2.
The crystal structure of the potential antitumor complex bis(2-acetyppyridine 3-hexamethyleneiminylthiosemicarbazonato)palladium(II) has been solved. The palladium(II) atom is in a square planar environment surrounded by two cis nitrogen atoms and two cis sulfur atoms. The ligands are not equivalent, one being tridentate with (N,N,S) donation, the other being monodentate using only the sulfur atom to coordinate to the metal. The tridentate ligand shows a Z, E, Z configuration while the monodentate ligand shows an E, E, Z. Intermolecular hydrogen bonds stabilize the structure, while the crystal packing is determined by Pd-C, Pd-pi, C-H-pi and pi-pi interactions.
潜在抗肿瘤配合物双（2-乙酰基吡啶3-六亚甲基亚氨基硫代半卡巴腙基）钯（II）的晶体结构已被解析。钯（II）原子处于平面正方形环境中，被两个顺式氮原子和两个顺式硫原子包围。配体并不等同，一个是通过（N，N，S）给予形成的三齿配体，另一个是仅用硫原子与金属配位的单齿配体。三齿配体呈现Z，E，Z构型，而单齿配体呈现E，E，Z构型。分子间氢键使结构稳定，而晶体堆积由Pd-C、Pd-π、C-H-π和π-π相互作用决定。
