帕金森病和阿尔茨海默病患者外周免疫系统炎症相关特征的相似性和差异性。
Similarity and Differences in Inflammation-Related Characteristics of the Peripheral Immune System of Patients with Parkinson's and Alzheimer's Diseases.
机构信息
Laboratory of Cell Interactions, Department of Immunology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.
出版信息
Int J Mol Sci. 2017 Dec 6;18(12):2633. doi: 10.3390/ijms18122633.
Abstract
Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common age-related neurodegenerative disorders. Both diseases are characterized by chronic inflammation in the brain-neuroinflammation. The first signs of PD and AD are most often manifested in old age, in which the immune system is usually characterized by chronic inflammation, so-called "inflammaging" In recent years, there is growing evidence that pathogenesis of these diseases is connected with both regional and peripheral immune processes. Currently, the association of clinical signs of PD and AD with different characteristics of patient immune status is actively being researched. In this mini-review we compare the association of PD and AD alterations of a number of immune system parameters connected with the process of inflammation.
摘要
帕金森病（PD）和阿尔茨海默病（AD）是最常见的与年龄相关的神经退行性疾病。这两种疾病的特点是大脑神经炎症的慢性炎症。PD 和 AD 的最初迹象通常在老年时表现出来，此时免疫系统通常以慢性炎症为特征，即所谓的“炎症老化”。近年来，越来越多的证据表明，这些疾病的发病机制与局部和外周免疫过程有关。目前，正在积极研究 PD 和 AD 的临床症状与患者免疫状态的不同特征之间的关联。在这篇迷你综述中，我们比较了 PD 和 AD 与炎症过程相关的一些免疫系统参数改变的关联。
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