Shores-Wilson Kathy, Biggs Melanie M, Miller Alexander L, Carmody Thomas J, Chiles John A, Rush A John, Crismon M Lynn, Toprac Marcia G, Witte Bradley P, Webster Joe C
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.
Int J Methods Psychiatr Res. 2002;11(1):45-53. doi: 10.1002/mpr.122.
This study compares ratings obtained with an itemized clinician-rated symptom severity measure--the 24-item Brief Psychiatric Rating Scale (BPRS24)--with a Physician Global Rating Scale (PhGRS) and a Patient Global Rating Scale (PtGRS) in assessing treatment outcomes in patients with schizophrenia (SCZ). A total of 91 patients (31 inpatients and 60 outpatients) with SCZ were enrolled in a feasibility study of the use of medication algorithms in the treatment of SCZ. Clinicians completed the BPRS24 and the PhGRS; patients completed the PtGRS at each visit. The analyses reported here were conducted using the original BPRS18 and four items from the BPRS18 that rate the positive symptoms of psychosis (the Positive Symptom Rating Scale or PSRS), comparing anchored with global rating scales and with one another. The PtGRS had the lowest effect size (0.8) and was negatively correlated with the other ratings in inpatients. The PhGRS was significantly correlated (0.46) with the BPRS18, but the same person completed both ratings. The effect size of the PhGRS (0.6) was generally lower than with the BPRS18 (1.4) in differentiating responders from non-responders. On average, the PSRS had a slightly lower effect size than the longer itemized BPRS18, but the results support its use as a quantitative rating in circumstances where it is not feasible to routinely use a lengthier scale.
本研究比较了在评估精神分裂症（SCZ）患者治疗结果时，使用逐项列出的临床医生评定的症状严重程度量表——24项简明精神病评定量表（BPRS24）所获得的评分，与医生整体评定量表（PhGRS）和患者整体评定量表（PtGRS）的评分。共有91例SCZ患者（31例住院患者和60例门诊患者）参与了一项关于使用药物治疗算法治疗SCZ的可行性研究。临床医生完成BPRS24和PhGRS；患者每次就诊时完成PtGRS。此处报告的分析使用的是原始的BPRS18以及BPRS18中评定精神病阳性症状的四个项目（阳性症状评定量表或PSRS），并与整体评定量表相互比较。PtGRS的效应量最低（0.8），且与住院患者的其他评定呈负相关。PhGRS与BPRS18显著相关（0.46），但这两项评定由同一人完成。在区分反应者与无反应者方面，PhGRS的效应量（0.6）总体上低于BPRS18（1.4）。平均而言，PSRS的效应量略低于较长的逐项列出的BPRS18，但结果支持在常规使用较长量表不可行的情况下，将其用作定量评定。
