松脂和生物活性软膏：水溶性成分对外周血中性粒细胞细胞因子产生的影响
Pine resin and biopin ointment: effects of water-soluble fractions on cytokine production by peripheral blood neutrophils.
作者信息
Simbirtsev A S, Konusova V G, McHedlidze G Sh, Paramonov B A, Chebotarev V Yu
机构信息
Institute of High-Purity Biological Preparations, St. Petersburg.
出版信息
Bull Exp Biol Med. 2002 Aug;134(2):151-5. doi: 10.1023/a:1021184214627.
We studied the effects of water-soluble fractions of pine resin and Biopin-10 and Biopin-20 ointments used for the therapy of burns, wounds, and purulent and inflammatory diseases on spontaneous and induced synthesis of tumor necrosis factor and interleukins 1, 2, and 8 by human peripheral blood neutrophils in vitro. These preparations contain various bioactive substances producing opposite and dose-dependent immunomodulatory effects. Our results indicate that the composition and doses of preparations should be selected to achieve the maximum therapeutic effect.
我们研究了用于烧伤、伤口以及化脓性和炎症性疾病治疗的松树树脂水溶性成分、Biopin - 10软膏和Biopin - 20软膏，对人外周血中性粒细胞体外自发合成及诱导合成肿瘤坏死因子、白细胞介素1、2和8的影响。这些制剂含有多种生物活性物质，会产生相反的剂量依赖性免疫调节作用。我们的结果表明，应选择制剂的成分和剂量以实现最大治疗效果。
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