胞壁酰二肽糖苷对淋巴细胞增殖及白细胞介素-2产生的影响。
Effects of muramyl dipeptide glycosides on lymphocyte proliferation and production of interleukin-2.
作者信息
Kalyuzhin O V, Zemlyakov A E, Kalyuzhina E V, Shkalev M V, Nelyubov M V
机构信息
Laboratory of Cell Immunopathology and Biotechnology, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow.
出版信息
Bull Exp Biol Med. 2002 Aug;134(2):161-4. doi: 10.1023/a:1021140432374.
We studied the effect of new muramyl dipeptide glycosides with different structure of aglycon and configuration glycoside bond on spontaneous and mitogen-induced proliferation of mouse splenocytes and production of interleukin-2 by these cells. Biological activity of muramyl dipeptide beta-glycosides with aliphatic, carbocyclic, adamantile, and phenol aglycons is higher than that of the original compound, while alpha-glycosylation decreases the immunostimulating effect of this glycopeptide.
我们研究了具有不同苷元结构和糖苷键构型的新型胞壁酰二肽糖苷对小鼠脾细胞自发增殖和丝裂原诱导增殖以及这些细胞白细胞介素-2产生的影响。具有脂肪族、碳环、金刚烷基和酚类苷元的胞壁酰二肽β-糖苷的生物活性高于原始化合物，而α-糖基化则降低了这种糖肽的免疫刺激作用。
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