Taraskina A E, Savicheva A M, Akopian T A, Soroka A E, Momynaliev K T, Govorun V M
Laboratory of Microbiology, D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg.
Bull Exp Biol Med. 2002 Jul;134(1):60-3. doi: 10.1023/a:1020664807029.
We studied the correlation between genetic transfer of tetM determinant in Tn916 conjugative transposon by urogenital mycoplasmas (Mycoplasma hominis and Ureaplasma urealyticum) and changes in the bacterial repertoire during treatment with a tetracycline antibiotic. Basic conditions favoring the nonspecific transfer of tetM determinant into mollicute cells are determined and the allele polymorphism of tetM determinant in clinical strains of M. hominis and U. urealyticum is evaluated. The structure of tetM gene in clinical mycoplasma and ureaplasma strains is characterized by a peculiar mosaic pattern and differs from all previously described alleles of this gene. The results suggest that tetracycline resistance in mollicutes is determined by mechanisms alternative to genetic transfer of tetM determinant.
我们研究了泌尿生殖道支原体（人型支原体和解脲脲原体）在Tn916接合转座子中tetM决定簇的基因转移与四环素抗生素治疗期间细菌种类变化之间的相关性。确定了有利于tetM决定簇非特异性转移到柔膜菌细胞中的基本条件，并评估了人型支原体和解脲脲原体临床菌株中tetM决定簇的等位基因多态性。临床支原体和脲原体菌株中tetM基因的结构具有独特的镶嵌模式，与该基因先前描述的所有等位基因不同。结果表明，柔膜菌对四环素的耐药性是由tetM决定簇基因转移以外的机制决定的。
