Pauwels P, Debiec-Rychter M, Sciot R, Vlasveld T, den Butter B, Hagemeijer A, Hogendoorn P C W
Stichting PAMM, Catharina Hospital, Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands.
Histopathology. 2002 Dec;41(6):526-30. doi: 10.1046/j.1365-2559.2002.01509.x.
Clear cell sarcoma is a high-grade sarcoma with morphological features resembling malignant melanoma. This tumour is reported to display a characteristic distribution pattern nearly always involving the extremities. We report the first case of clear cell sarcoma of the stomach.
A 30-year-old male developed a huge tumour of the stomach, which at first glance could be considered as a poorly differentiated carcinoma. Immunohistochemical and ultrastructural examinations were consistent with a diagnosis of metastatic melanoma. However, cytogenetic examination revealed a t(12;22) translocation, specific for clear cell sarcoma. This was confirmed by fluorescence in-situ hybridization.
Making a reliable diagnosis of clear cell sarcoma of the stomach requires cytogenetic or molecular diagnostic investigations, particularly to rule out metastatic melanoma. This diagnosis avoids an unnecessary search for a primary melanoma.
透明细胞肉瘤是一种高级别肉瘤，其形态学特征类似于恶性黑色素瘤。据报道，这种肿瘤呈现出几乎总是累及四肢的特征性分布模式。我们报告首例胃透明细胞肉瘤病例。
一名30岁男性胃部出现巨大肿瘤，乍一看可被认为是低分化癌。免疫组化和超微结构检查结果与转移性黑色素瘤的诊断相符。然而，细胞遗传学检查发现了透明细胞肉瘤特有的t(12;22)易位。荧光原位杂交证实了这一点。
要对胃透明细胞肉瘤做出可靠诊断，需要进行细胞遗传学或分子诊断检查，特别是要排除转移性黑色素瘤。这一诊断可避免不必要地寻找原发性黑色素瘤。
