Huang Yau-Li, Liao Yuan-Li, Lee Shih-Hung, Hong Hong-Shang
Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Dermatol Surg. 2002 Nov;28(11):1007-12; discussion 1012. doi: 10.1046/j.1524-4725.2002.02103.x.
Freckles are melanotic lesions frequently seen on the face and other sun-exposed areas. Previously evaluation of the severity of freckles has relied on the ultimately subjective assessment of the doctor or patient. Intense pulsed light (IPL) is newly introduced to treat facial freckles in Asian skin.
To determine the effectiveness of IPL treatment for Asian patients with freckled skin and to assess a new and objective method for evaluation of the severity of freckling and posttherapy improvement using an ultraviolet (UV)-sensitive camera and film.
Thirty-six patients with freckles were enlisted. IPL treatment was administered to patients with freckles in 4-week sessions. Irradiation wavelength was controlled using cutoff filters ranging from 550 to 590 nm, with a fluence of 25-35 J/cm2, with single- or double-pulse illumination and a pulse width of 4.0 msec. The assessments of the physician and patient were compared with the objective dermatologic evaluation with black-and-white and UV photography used to derive two treatment parameters, cosmetic density of freckles (CDF) and freckles area and severity index (FASI), which are applicable in a clinical setting.
By the end of the study, two attending physicians assessed the results for 86.1% of the subjects as excellent or good, with 91.7% of the patients reporting that they were extremely or very satisfied. A statistically significant improvement in mean FASI score was demonstrated at 6 months after treatment compared with baseline (n = 36, p <.005; paired t-test). Mean overall improvement rate (n = 36), as determined from the difference in mean FASI score, was 63% at 12 weeks and 58% at 6 months.
IPL is an effective and safe treatment for facial freckles in Asian skin, with relatively few adverse effects and high satisfaction levels.
雀斑是常见于面部和其他暴露于阳光下区域的黑素性损害。以前对雀斑严重程度的评估依赖于医生或患者最终的主观判断。强脉冲光（IPL）新近被用于治疗亚洲人群皮肤的面部雀斑。
确定IPL治疗亚洲雀斑皮肤患者的有效性，并评估一种使用紫外线（UV）敏感相机和胶片来评价雀斑严重程度及治疗后改善情况的新的客观方法。
招募了36例有雀斑的患者。对有雀斑的患者每4周进行一次IPL治疗。使用波长范围为550至590nm的截止滤光片控制照射波长，能量密度为25 - 35J/cm²，采用单脉冲或双脉冲照射，脉冲宽度为4.0毫秒。将医生和患者的评估结果与使用黑白摄影和UV摄影进行的客观皮肤学评估进行比较，以得出两个适用于临床的治疗参数，即雀斑的美容密度（CDF）和雀斑面积及严重程度指数（FASI）。
在研究结束时，两名主治医师将86.1%的受试者的治疗结果评估为优秀或良好，91.7%的患者报告他们极其满意或非常满意。与基线相比，治疗后6个月平均FASI评分有统计学显著改善（n = 36，p <.005；配对t检验）。根据平均FASI评分差异确定的平均总体改善率（n = 36）在12周时为63%，在6个月时为58%。
IPL是治疗亚洲人面部雀斑的一种有效且安全的方法，不良反应相对较少，满意度较高。
