Whitworth J A G, Mahe C, Mbulaiteye S M, Nakiyingi J, Ruberantwari A, Ojwiya A, Kamali A
Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe, Uganda.
Trop Med Int Health. 2002 Dec;7(12):1047-52. doi: 10.1046/j.1365-3156.2002.00973.x.
The objective of this study was to examine the epidemic trends of HIV-1 infection in a rural population cohort in Uganda followed for 10 years. The methods used were to assess incidence and prevalence trends in adults in this longitudinal cohort study. The results showed that incidence of infection has fallen significantly in all adults, and separately in males, females, young adults and older adults over the course of the study period. There was also a reduction in prevalence, especially in young men and women. There was some evidence of a cohort effect in women. The conclusions are that this study provides the first evidence of a falling incidence in a rural general population in Africa. This was an observational cohort exposed to national health education messages, giving hope that similar campaigns elsewhere in Africa could be used effectively in efforts to control the HIV epidemic.
本研究的目的是调查乌干达一个农村人口队列中10年间HIV-1感染的流行趋势。所采用的方法是在这项纵向队列研究中评估成年人的发病率和患病率趋势。结果显示，在研究期间，所有成年人以及男性、女性、年轻人和老年人的感染发病率均显著下降。患病率也有所降低，尤其是年轻男性和女性。有证据表明女性存在队列效应。结论是，本研究首次提供了非洲农村普通人群发病率下降的证据。这是一个接触国家健康教育信息的观察性队列，这给人们带来了希望，即非洲其他地区的类似运动可有效用于控制艾滋病流行的努力中。
