Amuron Barbara, Coutinho Alex, Grosskurth Heiner, Nabiryo Christine, Birungi Josephine, Namara Geoffrey, Levin Jonathan, Smith Peter G, Jaffar Shabbar
MRC/UVRI Uganda Research Unit on AIDS, c/o Medical Research Council/ Uganda Virus Research Institute, P.O. Box 49, Entebbe, Uganda.
Open AIDS J. 2007;1:21-7. doi: 10.2174/1874613600701010021. Epub 2007 Dec 13.
The scale-up of antiretroviral therapy is progressing rapidly in Africa but with a limited evidence-base. We report the baseline results from a large pragmatic cluster-randomised trial comparing different strategies of ART delivery. The trial is integrated in normal health service delivery. 1453 subjects were recruited into the study. Significantly more women (71%) than men (29%) were recruited. The WHO HIV clinical stage at presentation did not differ significantly between men and women: 58% and 53% respectively were at WHO stage III or IV (p=0.9). Median CD4 counts (IQR) x 106 cells/l were 98 (28, 160) among men and 111 (36, 166) among women. Sixty-four percent of women and 61% men had plasma viral load > or =100,000 copies. Baseline characteristics did not change over time. Considerably fewer men than women presented for treatment. Both men and women presented at an advanced stage with very low median CD4 count and high plasma viral load.
抗逆转录病毒疗法在非洲的推广进展迅速，但相关证据有限。我们报告了一项大型实用整群随机试验的基线结果，该试验比较了不同的抗逆转录病毒疗法给药策略。该试验融入了正常的医疗服务提供体系。1453名受试者被纳入研究。招募的女性（71%）明显多于男性（29%）。就诊时的世界卫生组织（WHO）HIV临床分期在男性和女性之间无显著差异：分别有58%和53%处于WHO III期或IV期（p = 0.9）。男性的CD4细胞计数中位数（四分位间距）×10⁶个/微升为98（28，160），女性为111（36，166）。64%的女性和61%的男性血浆病毒载量≥100,000拷贝。基线特征未随时间变化。前来接受治疗的男性比女性少得多。男性和女性就诊时均处于晚期，CD4细胞计数中位数很低，血浆病毒载量很高。
