Kamimura Motohiro, Matsuo Masaki, Miyahara Takashi, Kimura Karue, Matsumoto Kimiyo, Nakaya Tsuyoshi, Abe Tomiya, Akizawa Tadao
Center of Blood Purification Therapy, Wakayama Medical University, Wakayama, Japan.
Ther Apher. 2002 Dec;6(6):467-70. doi: 10.1046/j.1526-0968.2002.00470.x.
Peripheral arterial disease (PAD; arteriosclerosis obliterans) shows ischemic symptoms along the peripheral arteries due to reduced blood flow, and the number of patients with PAD is increasing. Several papers have reported on the clinical effect of low-density lipoprotein apheresis (LDL-A) on PAD, but there has been no report so far on the improvement of total peripheral artery stenosis by LDL-A. We report on the clinical course of a female PAD patient with intractable decubitus in her heel due to the complete occlusion of anterior tibial artery who was treated by a series of LDL-A sessions. The complete occlusion of the anterior tibial artery improved as seen on angiography, and the decubitus in her heel also markedly improved after LDL-A therapy. This report supports the clinical benefit of LDL-A for the treatment of PAD.
外周动脉疾病（PAD；闭塞性动脉硬化症）由于血流减少，沿外周动脉出现缺血症状，且PAD患者数量正在增加。多篇论文报道了低密度脂蛋白单采术（LDL-A）对PAD的临床疗效，但迄今为止，尚无关于LDL-A改善外周动脉总狭窄的报道。我们报告了一名女性PAD患者的临床病程，该患者因胫前动脉完全闭塞导致足跟顽固性褥疮，接受了一系列LDL-A治疗。血管造影显示胫前动脉完全闭塞有所改善，LDL-A治疗后足跟褥疮也明显改善。本报告支持LDL-A治疗PAD的临床益处。
