两性霉素B脂质复合物与多形核白细胞联合使用时，对多育赛多孢和尖端赛多孢具有相加抗真菌活性。

Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum.

作者信息

Gil-Lamaignere Cristina, Roilides Emmanuel, Maloukou Avgi, Georgopoulou Irene, Petrikkos George, Walsh Thomas J

机构信息

Third Paediatric Department, Aristotle University, Hippokration Hospital, Thessaloniki GR-54642, Greece.

出版信息

J Antimicrob Chemother. 2002 Dec;50(6):1027-30. doi: 10.1093/jac/dkf198.

DOI:10.1093/jac/dkf198

PMID:12461027

Abstract

Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes (PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.

摘要

多育赛多孢和尖端赛多孢对大多数抗真菌药物耐药，并可引起难治性肺部感染和播散性感染。采用XTT法评估了去氧胆酸盐两性霉素B、两性霉素B脂质复合物和脂质体两性霉素B与人多形核白细胞（PMN）联合作用对这些真菌菌丝的损伤情况。两性霉素B脂质复合物与PMN联合对两种赛多孢菌均显示出显著的相加作用（多育赛多孢为22%，尖端赛多孢为81%；P<0.04）。所有制剂均未对PMN的抗真菌活性产生不利影响。这些发现对于设计更好的策略来管理由这些微生物引起的感染可能具有重要意义。