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两性霉素B与米卡芬净对赛多孢菌属的体外协同相互作用

In vitro synergistic interaction between amphotericin B and micafungin against Scedosporium spp.

作者信息

Yustes Clara, Guarro Josep

机构信息

Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21, 43201 Reus, Spain.

出版信息

Antimicrob Agents Chemother. 2005 Aug;49(8):3498-500. doi: 10.1128/AAC.49.8.3498-3500.2005.

DOI:10.1128/AAC.49.8.3498-3500.2005
PMID:16048969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196235/
Abstract

The in vitro interaction between amphotericin B and micafungin against 36 isolates of Scedosporium spp. has been evaluated using checkerboard assays and the minimal effective concentration endpoint. Synergy was found for 82.4% of Scedosporium prolificans isolates and for 31.6% of Scedosporium apiospermum isolates. Antagonism was not observed.

摘要

已使用棋盘法测定和最低有效浓度终点评估了两性霉素B和米卡芬净对36株拟青霉属菌株的体外相互作用。发现82.4%的多育拟青霉分离株和31.6%的尖端拟青霉分离株存在协同作用。未观察到拮抗作用。

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