Kelly Lisa K, Porta Nicolas F m, Goodman Denise M, Carroll Christopher L, Steinhorn Robin H
Department of Pediatrics, Children's Memorial Hospital and Northwestern University Medical School, Chicago, Illinois 60614, USA.
J Pediatr. 2002 Dec;141(6):830-2. doi: 10.1067/mpd.2002.129849.
We report the use of inhaled prostacyclin (PGI(2)) in 4 neonates with persistent pulmonary hypertension and hypoxemia refractory to inhaled nitric oxide. Oxygenation rapidly improved after inhalation of PGI(2) in all infants. The condition of one infant subsequently deteriorated, and alveolar capillary dysplasia was found at autopsy. The surviving infants were discharged with normal oxygen saturations in room air.
我们报告了4例持续性肺动脉高压且对吸入一氧化氮治疗无效的低氧血症新生儿使用吸入性前列环素（PGI₂）的情况。所有婴儿吸入PGI₂后氧合迅速改善。其中一名婴儿的病情随后恶化，尸检发现肺泡毛细血管发育异常。存活的婴儿出院时在室内空气中血氧饱和度正常。
